Herbal Ingredients' Targets Database
Total information of HIT
| Entry |
Compound |
Herb |
Target |
Direct Target |
Reference |
| 5208 |
586 |
1305 |
1301 |
221 |
3258 |
Distribution of the compounds in the class of natural products
| Compound class |
NO. of compound (ratio) |
Examples |
| Terpenoids |
100 (17.06%) |
Tanshinone i, Tanshinone iiA |
| Alkaloids |
82 (13.99%) |
Yohimbine, Vincristine |
| Flavonoids |
80 (12.65%) |
(-)-Epigallocatechin-3-gallate, Quercetin |
| Simple Aromatic Natural Products |
52 (8.87%) |
Yohimbine, Vincristine |
| Aliphatic natural products |
42 (7.17%) |
Panaxydol, Nonanoic Acid |
| Steroids |
22 (3.75%) |
Withaferin A, Tigogenin |
| Carbohydrates |
19 (3.24%) |
Tubuloside b, Vitamin C |
| Lignans |
17 (2.90%) |
Sesamolin, (-)-Pinoresinol |
| Aminoacids and peptides |
10 (1.71%) |
Thyroglobulin, Betaine |
| Benzopyranoids |
10 (1.71%) |
Osthol, Nodakenin |
| Polycyclic aromatic natural products |
9 (1.54%) |
Sennoside A, Sennoside B |
| Tannins |
6 (1.02%) |
Chebulinic acid, Gallotannin |
| Oxygen heterocycles |
1 (0.17%) |
Anemonin |
| Benzofuranoids |
1 (0.17%) |
Senkyunolide A |
| Unknown |
122 (20.82%) |
Withanolide, Urogastrone |
Distribution of the targets by Molecular Function, according to PANTHER
| Molecular function |
NO. of Target(Ratio) |
NO. of Direct Target(Ratio) |
Examples |
| Receptor |
197(15.14%) |
45(20.36%) |
PPARA, RARA |
| Signaling molecule |
147(11.30%) |
21(9.55%) |
PDGFB, BCLX |
| Nucleic acid binding |
129(9.92%) |
25(11.31%) |
TEP1, PXR |
| Transcription factor |
124(9.53%) |
21(9.50%) |
PXR, STAT3 |
| Kinase |
105(8.07%) |
22(9.95.%) |
MP2K1, KS6B1 |
| Oxidoreductase |
102(7.84%) |
26(11.76%) |
NOS2A, FAS |
| Transferase |
77(5.92%) |
18(8.14%) |
OXSM, ST1E1 |
| Select regulatory molecule |
74(5.69%) |
6(2.71%) |
TOP2A, AAKG2 |
| Hydrolase |
69(5.30%) |
17(7.69%) |
LIPL, SIRT1 |
| Transporter |
64(4.92%) |
4(1.81%) |
MDR1, VMAT2 |
| Protease |
62(4.77%) |
15(6.79%) |
ASP6, CASP3 |
| Ion channel |
49(3.77%) |
19(8.60%) |
ITPR1, CFTR |
| Cell adhesion molecule |
40(3.07%) |
4(1.81%) |
ITA6, LYAM3 |
| Extracellular matrix |
38(2.92%) |
5(2.26%) |
MMP2, MMP9 |
| Defense/immunity protein |
36(2.77%) |
3(1.36%) |
C1R, CD4 |
| Miscellaneous function |
34(2.61%) |
1(0.45%) |
VIME, CAV1 |
| Transfer/carrier protein |
29(2.23%) |
1(0.45%) |
KPCB, ILBP |
| Select-calcium-binding-protein |
29(2.23%) |
8(3.62%) |
NOS2A, KPCB |
| Cytoskeletal protein |
25(1.92%) |
3(1.36%) |
TBA3, KTNA1 |
| Phosphatase |
24(1.84%) |
4(1.81%) |
PP2BA, CDKN3 |
| Synthase and synthetase |
24(1.84%) |
5(2.26%) |
OXSM, PGH2 |
| Lyase |
17(1.31%) |
3(1.36%) |
DCAM, ADCY |
| Ligase |
16(1.23%) |
1(0.45%) |
COA1, MDM2 |
| Chaperone |
14(1.07%) |
1(0.45%) |
AHSA1, GRP78 |
| Isomerase |
6(0.46%) |
1(0.45%) |
TOP2A, PTGES |
| Cell junction protein |
6(0.46%) |
-- |
CXA1, CLD4 |
| Membrane traffic protein |
6(0.46%) |
-- |
SYUA, STAR |
| Unknown |
117(8.99%) |
21(9.50%) |
RSSA, DYR |
Distribution of the targets by Subcellular Location, according to GO
| Subcellular location |
Number of Targets(Ratio) |
Number of Direct Targets(Ratio) |
Examples |
| Extracellular region |
301(23.14%) |
35(15.84%) |
IFNG, ALDR |
| Membrane |
661(50.81%) |
122(55.20%) |
ACHA, PI2R |
| Cytoplasm |
772(59.34%) |
147(66.52%) |
AOFA, CASP3 |
| Organelle |
773(59.42%) |
141(63.80%) |
TRPA1, COMT |
| Nucleus |
412(31.67%) |
7634.39% |
ZBT7A, ESR1 |
| Unknown |
38(2.92% |
20(9.05%) |
TYMP, DDC |
Last Updated on Oct 1th, 2010