Head-to-head Gene Database Statistics Information

The general statistic information about head-to-head gene paris in this database

Distribution of TSS Distance of Human, Mouse, Rat Head-to-Head Genes:

The chromosome distribution of head-to-head gene pairs in human

Chromosomes GeneNum ChrLength(bp) GeneDensity (per Mb) H2HpairNum
(I-pairNum*/ II-PairNum*) 		H2HGeneNum
(I-GeneNum*/ II-GeneNum*) 		H2H gene rate(%)
1 2782 247250 11 139(31/108) 275(62/213) 9.81
2 1888 242951 7 105(28/77) 207(55/152) 10.91
3 1469 199502 7 81(24/57) 159(47/112) 10.69
4 1154 191273 6 54(20/34) 107(39/68) 9.27
5 1268 180858 7 65(23/42) 129(46/83) 10.17
6 1505 170900 8 90(15/75) 176(30/146) 11.56
7 1452 158821 9 66(25/41) 131(50/81) 8.95
8 984 146275 6 44(13/31) 87(26/61) 8.74
9 1148 140273 8 67(24/43) 133(47/86) 11.5
10 1106 135375 8 54(11/43) 106(22/84) 9.49
11 1848 134452 13 87(21/66) 170(41/129) 9.15
12 1370 132350 10 67(12/55) 134(24/110) 9.71
13 551 114143 4 24(10/14) 48(20/28) 8.53
14 1275 106369 11 65(19/46) 124(36/88) 9.57
15 945 100339 9 42(15/27) 84(30/54) 8.89
16 1109 88827 12 79(20/59) 158(40/118) 13.98
17 1469 78775 18 97(19/78) 193(38/155) 13.14
18 432 76117 5 20(6/14) 40(12/28) 9.26
19 1695 63812 26 72(15/57) 142(29/113) 8.38
20 737 62436 11 27(4/23) 54(8/46) 7.19
21 352 46944 7 14(3/11) 28(6/22) 7.95
22 742 49691 14 34(8/26) 68(16/52) 9.16
X 1336 154914 8 52(17/35) 100(31/69) 7.41
Y 307 57773 5 2(0/2) 4(0/4) 1.3
Note:
  • h2h pairs were classified into two classes according to their TSS distance. H2h genes were classified accordingly
  • I:(-1000, 0), or overlapping;
  • II:(0, 1000), or non-overlapping

The chromosome distribution of head-to-head gene pairs in mouse

Chromosomes GeneNum ChrLength(bp) GeneDensity (per Mb) H2HpairNum
(I-pairNum/ II-PairNum) 		H2HGeneNum
(I-GeneNum/ II-GeneNum) 		H2H gene rate(%)
1 1819 197195 9 86(20/66) 160(38/122) 8.8
2 2455 181748 13 111(33/78) 221(66/155) 8.96
3 1579 159600 9 70(11/59) 132(20/112) 8.23
4 1881 155630 12 82(10/72) 162(20/142) 8.56
5 1773 152537 11 82(13/69) 164(26/138) 9.25
6 1906 149517 12 54(13/41) 106(26/80) 5.51
7 2908 152525 19 119(32/87) 236(63/173) 8.08
8 1446 131739 10 82(14/68) 163(27/136) 11.27
9 1640 124076 13 66(15/51) 130(30/100) 7.93
10 1412 129993 10 51(14/37) 99(27/72) 7.01
11 2095 121844 17 125(28/97) 244(50/194) 11.5
12 1371 121258 11 65(16/49) 126(31/95) 9.12
13 1401 120284 11 83(20/63) 152(34/118) 10.64
14 1538 125195 12 57(16/41) 113(32/81) 7.15
15 1091 103495 10 43(8/35) 86(16/70) 7.88
16 973 98319 9 41(9/32) 81(17/64) 8.22
17 1511 95273 15 82(17/65) 161(33/128) 10.59
18 823 90772 9 29(5/24) 58(10/48) 7.05
19 974 61342 15 54(6/48) 105(12/93) 10.78
X 1847 166650 11 49(8/41) 98(16/82) 5.31
Y 53 15903 3 0(0/0) 0(0/0) 0.0

The chromosome distribution of head-to-head gene pairs in rat

Chromosomes GeneNum ChrLength(bp) GeneDensity (per Mb) H2HpairNum
(I-pairNum/ II-PairNum) 		H2HGeneNum
(I-GeneNum/ II-GeneNum) 		H2H gene rate(%)
1 3507 267911 13 107(22/85) 214(44/170) 6.1
2 1779 258208 6 73(11/62) 146(22/124) 8.15
3 2089 171063 12 71(14/57) 142(28/114) 6.8
4 1722 187126 9 41(11/30) 82(22/60) 4.76
5 1604 173096 9 63(15/48) 126(30/96) 7.79
6 1196 147637 8 49(7/42) 98(14/84) 8.19
7 1695 143003 11 47(8/39) 94(16/78) 5.55
8 1452 129042 11 42(3/39) 84(6/78) 5.72
9 898 113440 7 35(8/27) 70(16/54) 7.8
10 1869 110719 16 82(19/63) 164(38/126) 8.72
11 700 87760 7 21(5/16) 42(10/32) 6.0
12 715 46782 15 34(7/27) 68(14/54) 9.51
13 823 111155 7 21(4/17) 42(8/34) 5.1
14 894 112194 7 33(11/22) 66(22/44) 7.38
15 1008 109759 9 45(6/39) 90(12/78) 8.93
16 775 90239 8 29(2/27) 58(4/54) 7.48
17 834 97296 8 34(6/28) 67(12/55) 8.03
18 654 87265 7 17(5/12) 34(10/24) 5.05
19 656 59218 11 40(4/36) 80(8/72) 12.2
20 844 55268 15 17(3/14) 34(6/28) 4.03
X 1222 160699 7 30(8/22) 60(16/44) 4.91

Functions Associated with h2h Pairs in the “Biological Process” (BP), “Molecular Function” (MF), and “Cellular Component” (CC) in GO system

GO Accession GO Term H2H Pairs Ontology
GO:0000074 regulation of progression through cell cycle 1/0/0 BP
GO:0006091 generation of precursor metabolites and energy 1/0/0 BP
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 15/13/4 BP
GO:0006164 purine nucleotide biosynthetic process 1/1/1 BP
GO:0006259 DNA metabolic process 2/1/1 BP
GO:0006281 DNA repair 1/1/0 BP
GO:0006334 nucleosome assembly 8/13/1 BP
GO:0006350 transcription 1/0/1 BP
GO:0006351 transcription, DNA-dependent 0/0/1 BP
GO:0006355 regulation of transcription, DNA-dependent 10/3/0 BP
GO:0006364 rRNA processing 1/1/0 BP
GO:0006366 transcription from RNA polymerase II promoter 1/0/0 BP
GO:0006397 mRNA processing 1/0/0 BP
GO:0006412 translation 2/2/0 BP
GO:0006427 histidyl-tRNA aminoacylation 1/1/0 BP
GO:0006457 protein folding 2/2/0 BP
GO:0006464 protein modification 3/2/1 BP
GO:0006512 ubiquitin cycle 2/2/0 BP
GO:0006520 amino acid metabolic process 0/1/0 BP
GO:0006635 fatty acid beta-oxidation 1/1/0 BP
GO:0006810 transport 7/5/0 BP
GO:0006817 phosphate transport 3/2/0 BP
GO:0006915 apoptosis 1/0/0 BP
GO:0006950 response to stress 1/1/2 BP
GO:0006955 immune response 1/2/0 BP
GO:0006974 response to DNA damage stimulus 1/0/0 BP
GO:0006986 response to unfolded protein 2/2/0 BP
GO:0006996 organelle organization and biogenesis 2/5/0 BP
GO:0006997 nuclear organization and biogenesis 1/1/0 BP
GO:0007018 microtubule-based movement 1/0/0 BP
GO:0007049 cell cycle 0/1/0 BP
GO:0007154 cell communication 2/1/1 BP
GO:0007155 cell adhesion 0/3/0 BP
GO:0007165 signal transduction 2/2/1 BP
GO:0007186 G-protein coupled receptor protein signaling pathway 1/0/0 BP
GO:0007242 intracellular signaling cascade 2/0/0 BP
GO:0007275 multicellular organismal development 0/0/1 BP
GO:0007276 gametogenesis 1/1/0 BP
GO:0007517 muscle development 0/1/1 BP
GO:0007584 response to nutrient 0/0/1 BP
GO:0008150 biological_process 32/58/5 BP
GO:0008152 metabolic process 4/5/0 BP
GO:0008272 sulfate transport 1/0/0 BP
GO:0008283 cell proliferation 1/0/0 BP
GO:0008380 RNA splicing 1/0/0 BP
GO:0009058 biosynthetic process 1/2/0 BP
GO:0009059 macromolecule biosynthetic process 3/1/1 BP
GO:0009113 purine base biosynthetic process 1/0/0 BP
GO:0009408 response to heat 0/1/1 BP
GO:0009440 cyanate catabolic process 1/0/0 BP
GO:0009607 response to biotic stimulus 0/1/0 BP
GO:0009653 anatomical structure morphogenesis 2/1/0 BP
GO:0009719 response to endogenous stimulus 1/0/0 BP
GO:0009987 cellular process 98/103/33 BP
GO:0015031 protein transport 1/1/0 BP
GO:0015672 monovalent inorganic cation transport 1/1/0 BP
GO:0016043 cell organization and biogenesis 10/7/2 BP
GO:0016070 RNA metabolic process 10/12/2 BP
GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1/0/0 BP
GO:0019538 protein metabolic process 0/1/1 BP
GO:0019882 antigen processing and presentation 0/0/1 BP
GO:0019953 sexual reproduction 0/0/1 BP
GO:0022402 cell cycle process 1/0/0 BP
GO:0030154 cell differentiation 1/2/0 BP
GO:0030163 protein catabolic process 1/1/0 BP
GO:0030300 regulation of cholesterol absorption 0/0/1 BP
GO:0030301 cholesterol transport 0/0/1 BP
GO:0031323 regulation of cellular metabolic process 2/1/1 BP
GO:0032501 multicellular organismal process 2/1/0 BP
GO:0032502 developmental process 2/1/0 BP
GO:0032787 monocarboxylic acid metabolic process 1/0/0 BP
GO:0042127 regulation of cell proliferation 0/1/0 BP
GO:0042493 response to drug 0/0/1 BP
GO:0042981 regulation of apoptosis 2/1/0 BP
GO:0043066 negative regulation of apoptosis 1/1/0 BP
GO:0043170 macromolecule metabolic process 33/28/7 BP
GO:0043283 biopolymer metabolic process 29/30/6 BP
GO:0043285 biopolymer catabolic process 1/0/0 BP
GO:0044237 cellular metabolic process 82/69/17 BP
GO:0044238 primary metabolic process 72/60/13 BP
GO:0044249 cellular biosynthetic process 3/2/1 BP
GO:0044260 cellular macromolecule metabolic process 1/0/0 BP
GO:0044265 cellular macromolecule catabolic process 2/0/0 BP
GO:0044267 cellular protein metabolic process 22/22/6 BP
GO:0045449 regulation of transcription 2/2/0 BP
GO:0045859 regulation of protein kinase activity 1/0/0 BP
GO:0046907 intracellular transport 2/1/0 BP
GO:0048468 cell development 2/1/0 BP
GO:0048513 organ development 1/0/0 BP
GO:0048518 positive regulation of biological process 1/1/0 BP
GO:0048856 anatomical structure development 1/0/1 BP
GO:0050789 regulation of biological process 2/0/0 BP
GO:0050794 regulation of cellular process 9/8/4 BP
GO:0050877 neurological process 1/0/0 BP
GO:0050896 response to stimulus 1/3/1 BP
GO:0051179 localization 2/1/1 BP
GO:0051258 protein polymerization 1/0/0 BP
GO:0051338 regulation of transferase activity 1/0/0 BP
GO:0065007 biological regulation 1/0/0 BP
GO:0000267 cell fraction 3/0/1 CC
GO:0000786 nucleosome 8/13/1 CC
GO:0005575 cellular_component 28/55/6 CC
GO:0005587 collagen type IV 3/2/1 CC
GO:0005615 extracellular space 0/4/3 CC
GO:0005622 intracellular 19/18/1 CC
GO:0005624 membrane fraction 1/1/0 CC
GO:0005625 soluble fraction 0/1/1 CC
GO:0005634 nucleus 58/54/6 CC
GO:0005654 nucleoplasm 0/1/0 CC
GO:0005681 spliceosome 1/0/0 CC
GO:0005730 nucleolus 1/0/0 CC
GO:0005737 cytoplasm 25/18/5 CC
GO:0005739 mitochondrion 6/7/2 CC
GO:0005740 mitochondrial envelope 1/1/0 CC
GO:0005743 mitochondrial inner membrane 1/1/1 CC
GO:0005759 mitochondrial matrix 1/0/0 CC
GO:0005783 endoplasmic reticulum 2/3/0 CC
GO:0005794 Golgi apparatus 1/1/0 CC
GO:0005829 cytosol 2/2/0 CC
GO:0005840 ribosome 1/1/0 CC
GO:0005874 microtubule 1/0/0 CC
GO:0005887 integral to plasma membrane 1/0/0 CC
GO:0012505 endomembrane system 1/0/0 CC
GO:0015630 microtubule cytoskeleton 0/1/0 CC
GO:0016020 membrane 8/10/2 CC
GO:0016021 integral to membrane 23/25/3 CC
GO:0030529 ribonucleoprotein complex 2/2/0 CC
GO:0031090 organelle membrane 2/0/1 CC
GO:0031967 organelle envelope 1/0/0 CC
GO:0043190 ATP-binding cassette (ABC) transporter complex 0/0/1 CC
GO:0043229 intracellular organelle 14/13/4 CC
GO:0043231 intracellular membrane-bound organelle 67/73/17 CC
GO:0043232 intracellular non-membrane-bound organelle 6/7/1 CC
GO:0043233 organelle lumen 1/0/1 CC
GO:0043234 protein complex 18/13/6 CC
GO:0044424 intracellular part 15/11/6 CC
GO:0044425 membrane part 5/6/1 CC
GO:0044428 nuclear part 6/4/1 CC
GO:0044429 mitochondrial part 1/1/0 CC
GO:0044430 cytoskeletal part 0/2/0 CC
GO:0044444 cytoplasmic part 31/33/13 CC
GO:0044446 intracellular organelle part 21/16/5 CC
GO:0044455 mitochondrial membrane part 0/0/1 CC
GO:0044459 plasma membrane part 1/0/0 CC
GO:0044464 cell part 58/59/12 CC
GO:0000166 nucleotide binding 2/3/0 MF
GO:0003674 molecular_function 141/161/35 MF
GO:0003676 nucleic acid binding 18/18/2 MF
GO:0003677 DNA binding 17/15/2 MF
GO:0003700 transcription factor activity 2/0/0 MF
GO:0003713 transcription coactivator activity 1/0/0 MF
GO:0003723 RNA binding 5/3/0 MF
GO:0003735 structural constituent of ribosome 1/1/0 MF
GO:0003824 catalytic activity 59/53/9 MF
GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity 1/0/0 MF
GO:0003924 GTPase activity 1/0/0 MF
GO:0004300 enoyl-CoA hydratase activity 1/0/0 MF
GO:0004519 endonuclease activity 1/1/0 MF
GO:0004527 exonuclease activity 1/0/0 MF
GO:0004792 thiosulfate sulfurtransferase activity 1/0/0 MF
GO:0004821 histidine-tRNA ligase activity 1/1/0 MF
GO:0004867 serine-type endopeptidase inhibitor activity 0/1/0 MF
GO:0004871 signal transducer activity 2/1/0 MF
GO:0004872 receptor activity 1/0/0 MF
GO:0005041 low-density lipoprotein receptor activity 1/0/0 MF
GO:0005044 scavenger receptor activity 1/0/0 MF
GO:0005198 structural molecule activity 1/1/0 MF
GO:0005201 extracellular matrix structural constituent 3/0/0 MF
GO:0005386 carrier activity 0/1/0 MF
GO:0005488 binding 125/122/20 MF
GO:0005509 calcium ion binding 0/1/1 MF
GO:0005515 protein binding 50/44/14 MF
GO:0005524 ATP binding 10/15/0 MF
GO:0005525 GTP binding 1/0/0 MF
GO:0008009 chemokine activity 1/0/0 MF
GO:0008026 ATP-dependent helicase activity 1/1/0 MF
GO:0008067 metabotropic glutamate, GABA-B-like receptor activity 0/1/0 MF
GO:0008134 transcription factor binding 2/0/1 MF
GO:0008135 translation factor activity, nucleic acid binding 1/0/1 MF
GO:0008168 methyltransferase activity 1/1/0 MF
GO:0008270 zinc ion binding 12/8/0 MF
GO:0008324 cation transporter activity 1/1/0 MF
GO:0016301 kinase activity 1/1/0 MF
GO:0016408 C-acyltransferase activity 1/0/0 MF
GO:0016740 transferase activity 6/7/0 MF
GO:0016772 transferase activity, transferring phosphorus-containing groups 1/1/1 MF
GO:0016779 nucleotidyltransferase activity 1/1/0 MF
GO:0016787 hydrolase activity 5/8/1 MF
GO:0016887 ATPase activity 1/1/0 MF
GO:0017076 purine nucleotide binding 1/1/0 MF
GO:0017111 nucleoside-triphosphatase activity 0/1/0 MF
GO:0017127 cholesterol transporter activity 0/0/1 MF
GO:0030020 extracellular matrix structural constituent conferring tensile strength 0/2/0 MF
GO:0030528 transcription regulator activity 1/1/0 MF
GO:0030554 adenyl nucleotide binding 2/2/0 MF
GO:0043169 cation binding 7/7/0 MF
GO:0046872 metal ion binding 11/11/0 MF
GO:0046914 transition metal ion binding 6/4/0 MF
GO:0051082 unfolded protein binding 1/1/0 MF
GO:0051087 chaperone binding 1/0/0 MF