About this database

DBH2H is a database of head-to-head genes in human, mouse, rat, chicken and fugu. Head-to-head (h2h) gene pairs with their Transcription Start Sites (TSSs) less than 1kb apart were identified in five vertebrates: human, mouse, rat, chicken and fugu. H2h Genes were identified with entrez Gene IDs and official symbols, and were linked to genetic disorder information from OMIM database. Basic analyses of their genome occurrences and structure properties were performed.

In the DNA sequences provided for each h2h block, sequential features such as CpG islands, SNPs and TFBSs were specifically pointed out. Moving from sequence to function, calculated expression correlations and shared function terms were associated with these h2h pairs. In summary, this database, by providing comprehensive DNA, transcript and protein level information for large-scale head-to-head gene pairs, should largely benefit contemporary researchers who are interested in bi-directional promoter-driven.

 

A Schematic Illustration of Head-to-Head Gene Organization

A Schematic Illustration of Head-to-Head Gene Organization

Nonoverlapping (A) and overlapping (B) head-to-head gene pairs, respectively.

 

Reference

Yuan-Yuan Li, Hui Yu, Zong-Ming Guo, Ting-Qing Guo, Kang Tu, Yi-Xue Li. Systematic analysis of head-to-head gene organization: evolutionary conservation and potential biological relevance. PLOS Computational Biology. 2006 Jul 7; 2(7): e74. Epub 2006 May 15.

[PubMed: 16839196]

pubmed

 

For correspondence, please contact Dr. Yuan-Yuan Li, yyli@scbit.org.

For technological problem, please contact web administrator, lifecenter@scbit.org.

 

Release Information

The current is version 1.1 released in October, 2008